Blood transcriptomics provide valuable insights into the expression and abundance of all transcripts on a system-wide scale. The development of high-throughput RNA-Seq technologies accelerates the discovery of biomarkers and revolutionizes our understanding of drug responses, pathological and physiological processes, and the non-invasive diagnosis of diseases.

Lexogen’s Blood RNA-Seq Services provide customizable transcriptome analysis of whole blood samples and other biofluids, including nucleic acid extraction from standarized blood collection tubes, whole transcriptome sequencing, large-scale gene expression studies, and combined DNA sequencing of blood samples.

With decades of experience in transcriptomics, genomics, and related fields of biology, our bioinformatics team is empowered to tailor new bioinformatics developments to your unique project. We offer various Custom Bioinformatics Solutions, including new tool and pipeline developments, by using state-of-the-art algorithms and computational methods. With our personal and customized approach, we deliver most reliable and accurate outcomes enabling you to differentiate and drive innovation. Post-project, we provide detailed documentation and reporting, as well as secure and full transfer of custom pipeline.

RNA sequencing is a powerful technique for studying gene expression. To simply quantify differentially expressed genes between conditions or samples, 3′ mRNA sequencing is a cost-effective and efficient choice. For a comprehensive analysis, including detection of isoforms, single nucleotide polymorphisms (SNPs), and splicing variants, full-length mRNA sequencing is the preferred method. Selecting the appropriate RNA-Seq approach is essential for obtaining reliable and meaningful results.

Gene Expression Profiling service provides a cost-efficient genome-wide analysis of gene expression using Lexogen’s proprietary QuantSeq technology, targeting 3’ ends of mRNA molecules. QuantSeq technology offers a perfect solution for identifying and comparing gene expression levels between experimental groups, be it treatment, different genotypes, or disease-related research. As input material, we use total RNA. No prior poly(A) enrichment or rRNA depletion is needed.

Single‐cell RNA sequencing (scRNA‐seq) has become the state‐of‐the‐art approach for studying the heterogeneity and complexity of transcripts within individual cells. scRNA-Seq allows us to characterize and distinguish cells at the transcriptome level, enabling us to identify rare but functionally significant cell populations in health and disease and tackle experimental questions that cannot be answered using the bulk analysis approach.

Small RNAs (sRNAs) are less than 200 nt long, usually non-coding RNA molecules, that have key functional roles in mRNA turnover, translational regulation, and chromatin compaction, among others, and are important regulators of gene expression. MicroRNAs (miRNAs) are the most well-known and studied class of small RNAs, which modulate protein expression through post-transcriptional regulation. Abnormal mechanisms of miRNAs are reported in various diseases, especially cancer. Nowadays, many miRNAs serve as biomarkers of cancer.

Lexogen’s Small RNA Sequencing service allows you to get a complete small RNA profile across the entire transcriptome, from miRNAs and siRNAs to piRNAs, snoRNAs, and others.